Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.51 |
| ▸ | MMP1 | P03956 | 6/20 | 0.51 |
| ▸ | MMP3 | P08254 | 6/20 | 0.51 |
| ▸ | PDE4A | P27815 | 5/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303121 | 0.87 | MMP2 (0.60) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7308918 | 0.81 | FCER2 (0.48) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7308706 | 0.81 | MMP1 (0.46) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7303135 | 0.77 | MME (0.47) | MMP2MMP1MMP9MMP8MMP13 | |
| SCHEMBL7309199 | 0.75 | NFE2L2 (0.44) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7309205 | 0.75 | MMP2 (0.51) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7299652 | 0.74 | MME (0.44) | MMP1 | |
| SCHEMBL8203704 | 0.74 | MMP3 (0.63) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL7312804 | 0.73 | MMP1 (0.50) | MMP2MMP1MMP3PDE4APDE4B | |
| SCHEMBL27477945 | 0.72 | PPARG (0.47) | MMP2MMP9MMP8HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |