Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FCER2 | P06734 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303135 | 0.84 | MME (0.47) | FCER2MMEMMP2MMP9MMP8 | |
| SCHEMBL7308706 | 0.83 | MMP1 (0.46) | MMEMMP2LTA4HANPEPECE1 | |
| SCHEMBL7303121 | 0.82 | MMP2 (0.60) | MMEMMP2MMP9MMP8LTA4H | |
| SCHEMBL7303711 | 0.81 | MMP2 (0.51) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7299652 | 0.81 | MME (0.44) | FCER2MMELTA4HANPEPECE1 | |
| SCHEMBL27477944 | 0.78 | MME (0.42) | FCER2MMELTA4HANPEPECE1 | |
| SCHEMBL27477945 | 0.76 | PPARG (0.47) | MMEMMP2MMP9MMP8LTA4H | |
| SCHEMBL7299665 | 0.73 | MME (0.42) | FCER2MMEMMP2MMP9MMP8 | |
| SCHEMBL7309199 | 0.72 | NFE2L2 (0.44) | MMEMMP2LTA4HANPEPECE1 | |
| SCHEMBL7302160 | 0.72 | PDE4A (0.69) | FCER2MMP2MMP9MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |