Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 6/20 | 0.55 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP7 | P09237 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475586 | 0.78 | MMP3 (0.60) | MMP3TSHRPOLB | |
| SCHEMBL21491418 | 0.74 | NSD2 (0.45) | LSSNSD2TAS2R14TSHRPOLB | |
| SCHEMBL5118098 | 0.73 | NSD2 (0.63) | NSD2TAS2R14HTTTMEM97SIGMAR1 | |
| SCHEMBL14183081 | 0.72 | POLB (0.59) | MMP13MMP12NSD2TAS2R14HTT | |
| SCHEMBL14136361 | 0.72 | TAS2R14 (0.53) | LSSTAS2R14STAT3HTTTSHR | |
| SCHEMBL8185095 | 0.71 | HTT (0.62) | MMP3MMP13MMP12MMP2HTT | |
| SCHEMBL2338967 | 0.70 | MAPT (0.58) | MMP13MMP12TAS2R14MMP2HTT | |
| SCHEMBL7464731 | 0.69 | SNCA (0.58) | MMP13MMP12NSD2TAS2R14HTT | |
| SCHEMBL7401773 | 0.69 | HTT (0.51) | MMP13MMP12NSD2TAS2R14HTT | |
| SCHEMBL5317577 | 0.68 | NSD2 (0.61) | MMP3NSD2TAS2R14MMP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931788-B1 | Metalloprotease inhibitors | PFIZER LTD (GB) | 2002-11-06 | — | — | EP | disclosed |
| US-6090852-A | MATRIX METALLOPROTEASE INHIBITOR | PFIZER INC (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0931788-A2 | Metalloprotease inhibitors | Pfizer Limited (GB) | 1999-07-28 | — | — | EP | disclosed |