Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 15/20 | 0.50 |
| ▸ | ACE | P12821 | 10/20 | 0.50 |
| ▸ | CPA1 | P15085 | 10/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 10/20 | 0.50 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338879 | 1.00 | MME (0.50) | MMEACECPA1ACE2GPR88 | |
| SCHEMBL7333784 | 0.85 | CPA3 (0.52) | MMEACEGPR88 | |
| SCHEMBL7315467 | 0.85 | CPA3 (0.52) | MMEACEGPR88 | |
| SCHEMBL7323948 | 0.85 | CPA3 (0.52) | MMEACEGPR88 | |
| SCHEMBL7313773 | 0.85 | CPA3 (0.52) | MMEACEGPR88 | |
| SCHEMBL8641283 | 0.77 | MME (0.66) | MMEACECPA1ACE2GPR88 | |
| SCHEMBL7315209 | 0.77 | PTGS2 (0.40) | MMEACECPA1ACE2 | |
| SCHEMBL7312449 | 0.77 | CPA3 (0.43) | MMEACE | |
| SCHEMBL10883595 | 0.75 | ALPI (0.56) | — | |
| SCHEMBL7315216 | 0.75 | ECE1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | claimed |
| EP-0805817-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2001-08-16 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| EP-0805817-A1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022998-A1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |