Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 5/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.65 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.65 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.65 |
| ▸ | PLG | P00747 | 1/20 | 0.65 |
| ▸ | C1S | P09871 | 1/20 | 0.65 |
| ▸ | F10 | P00742 | 2/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.50 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | MASP2 | O00187 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11682104 | 0.98 | PRSS1 (0.62) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL9449832 | 0.83 | PLA2G10 (0.53) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL6940225 | 0.82 | ITGB3 (0.73) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL24263917 | 0.80 | F2 (0.65) | F2PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL8045403 | 0.80 | ITGB3 (0.71) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL4194796 | 0.80 | CA2 (0.46) | LMNA | |
| SCHEMBL9449852 | 0.79 | CA2 (0.64) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL18892653 | 0.79 | ALDH1A1 (0.43) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL1329642 | 0.78 | F2 (1.00) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL11409409 | 0.77 | F2 (0.71) | F2PRSS1PRSS2PRSS3PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |