Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 known ✓ | P00742 | 2/20 | 0.52 |
| ▸ | F2 | P00734 | 6/20 | 0.71 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.71 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.71 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.71 |
| ▸ | PLG | P00747 | 1/20 | 0.71 |
| ▸ | C1S | P09871 | 1/20 | 0.71 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.50 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.47 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MASP2 | O00187 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1329642 | 0.83 | F2 (1.00) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL22873499 | 0.79 | PRSS1 (0.67) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL6940225 | 0.79 | ITGB3 (0.73) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL24263917 | 0.77 | F2 (0.65) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL7310517 | 0.77 | F2 (0.65) | F2PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL8045403 | 0.77 | ITGB3 (0.71) | F2PRSS1PRSS2PRSS3PLG | |
| Hydrochloric Acid SCHEMBL11682104 | 0.76 | PRSS1 (0.62) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL20012321 | 0.75 | PRSS1 (0.61) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL14813070 | 0.72 | CTBP2 (0.48) | LMNA | |
| SCHEMBL14813077 | 0.72 | CA1 (0.50) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4214093-A | PROTEOLYTIC ENZYME INHIBITORS | TORII & CO., LTD. (JP) | 1980-07-22 | — | — | US | disclosed |