Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | TRIP13 | Q15645 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310798 | 1.00 | MMP2 (0.41) | MMP2MMP9CTSKRAB9ANPC1 | |
| SCHEMBL7305924 | 0.98 | CTSK (0.43) | MMP2MMP9CTSKRAB9ANPC1 | |
| SCHEMBL31630289 | 0.82 | MMP2 (0.43) | MMP2MMP9CTSKRAB9ANPC1 | |
| SCHEMBL7311871 | 0.80 | SMN1; SMN2 (0.44) | MMP2MMP9CTSKRAB9ANPC1 | |
| SCHEMBL7311882 | 0.80 | SMN1; SMN2 (0.44) | MMP2MMP9CTSKRAB9ANPC1 | |
| SCHEMBL7311878 | 0.80 | SMN1; SMN2 (0.44) | MMP2MMP9CTSKRAB9ANPC1 | |
| SCHEMBL7308764 | 0.78 | SMN1; SMN2 (0.47) | MMP2MMP9CTSKRAB9ANPC1 | |
| Anisole SCHEMBL7310806 | 0.76 | SCN9A (0.42) | MMP2MMP9RAB9ANPC1ALDH1A1 | |
| SCHEMBL7302689 | 0.75 | MMP9 (0.74) | MMP2MMP9SMN1; SMN2SCN9ASTS | |
| SCHEMBL7302697 | 0.75 | MMP9 (0.74) | MMP2MMP9SMN1; SMN2SCN9ASTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |