Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 6/20 | 0.42 |
| ▸ | MMP1 | P03956 | 5/20 | 0.42 |
| ▸ | MMP9 | P14780 | 4/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP8 | P22894 | 4/20 | 0.41 |
| ▸ | MMP12 | P39900 | 4/20 | 0.41 |
| ▸ | MMP14 | P50281 | 4/20 | 0.41 |
| ▸ | MMP16 | P51512 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 3/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324047 | 0.93 | GABRG2 (0.42) | GABRG2GABRB3GABRA3FFAR4LMNA | |
| SCHEMBL7321745 | 0.92 | MMP13 (0.49) | GABRG2GABRB3GABRA3FFAR4MMP13 | |
| SCHEMBL7311850 | 0.91 | KDM4E (0.42) | LMNAGAAMMP13MMP1MMP9 | |
| SCHEMBL7354583 | 0.91 | MMP13 (0.44) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7311156 | 0.89 | KDM4E (0.44) | FFAR4MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7323468 | 0.87 | MMP1 (0.46) | MMP13MMP1MMP9ADAM17KDM4E | |
| SCHEMBL7311675 | 0.86 | MMP1 (0.47) | GAAMMP13MMP1MMP9ADAM17 | |
| SCHEMBL7316847 | 0.86 | MMP9 (0.41) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7352954 | 0.86 | KAT6A (0.40) | GAAMMP13MMP1MMP9ADAM17 | |
| SCHEMBL7319588 | 0.86 | MAPT (0.39) | LMNAMMP13MMP1MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |