Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 13/20 | 0.44 |
| ▸ | MMP9 | P14780 | 12/20 | 0.44 |
| ▸ | MMP1 | P03956 | 10/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.40 |
| ▸ | MMP8 | P22894 | 6/20 | 0.40 |
| ▸ | MMP12 | P39900 | 4/20 | 0.40 |
| ▸ | MMP14 | P50281 | 4/20 | 0.40 |
| ▸ | MMP16 | P51512 | 4/20 | 0.40 |
| ▸ | MMP3 | P08254 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317430 | 0.93 | MMP9 (0.44) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7310011 | 0.92 | MMP13 (0.51) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7311368 | 0.91 | METAP2 (0.43) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7311850 | 0.89 | KDM4E (0.42) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7349832 | 0.89 | MMP9 (0.41) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7311156 | 0.87 | KDM4E (0.44) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7323468 | 0.85 | MMP1 (0.46) | MMP13MMP9MMP1ADAM17KDM4E | |
| SCHEMBL7321745 | 0.85 | MMP13 (0.49) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7319588 | 0.84 | MAPT (0.39) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7352954 | 0.84 | KAT6A (0.40) | MMP13MMP9MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |