Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 5/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788078 | 0.78 | RAB9A (0.43) | BACE1RAPGEF4KMT2AMEN1KDM4E | |
| SCHEMBL5765529 | 0.77 | KMT2A (0.50) | BACE1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL23794889 | 0.76 | MEN1 (0.64) | ABCG2ABCB1ABCC1EGFRRAPGEF4 | |
| SCHEMBL29961149 | 0.74 | RAPGEF4 (0.61) | ABCG2EGFRRAPGEF4KMT2AMEN1 | |
| SCHEMBL1687027 | 0.74 | RAPGEF4 (0.61) | ABCG2EGFRRAPGEF4KMT2AMEN1 | |
| SCHEMBL29961547 | 0.74 | RAPGEF4 (0.61) | ABCG2EGFRRAPGEF4KMT2AMEN1 | |
| SCHEMBL28008373 | 0.72 | ERBB2 (0.43) | EGFR | |
| SCHEMBL8842378 | 0.71 | KDR (0.46) | ABCG2ABCB1ABCC1EGFRRAPGEF4 | |
| SCHEMBL8471004 | 0.70 | EGFR (0.53) | ABCG2ABCB1ABCC1EGFRRAPGEF4 | |
| SCHEMBL7564951 | 0.70 | KDR (0.58) | ABCG2ABCB1ABCC1EGFRRAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |