Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23794887 | 0.79 | RAB9A (0.60) | KMT2AMAPTMEN1RAB9AMAPK1 | |
| SCHEMBL5788078 | 0.79 | RAB9A (0.43) | KMT2AMAPTMEN1RAB9AKDM4E | |
| SCHEMBL23794893 | 0.79 | MAPT (0.48) | KMT2AMAPTMEN1RAB9AKDM4E | |
| SCHEMBL23794891 | 0.79 | MAPK10 (0.50) | KMT2AMAPTMEN1RAB9AHSD17B10 | |
| SCHEMBL23794894 | 0.79 | AURKA (0.49) | KMT2AMAPTMEN1RAB9AAURKA | |
| SCHEMBL73115 | 0.77 | BACE1 (0.45) | KMT2AMEN1KDM4EALDH1A1BACE1 | |
| SCHEMBL23794897 | 0.75 | ROCK1 (0.51) | KMT2AMAPTMEN1RAB9AHSD17B10 | |
| SCHEMBL23794892 | 0.75 | KMT2A (0.48) | KMT2A | |
| SCHEMBL23794896 | 0.75 | RAB9A (0.59) | KMT2AMAPTMEN1RAB9ATDP1 | |
| SCHEMBL23794889 | 0.74 | MEN1 (0.64) | KMT2AMAPTMEN1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648892-A2 | ARYL-SUBSTITUTED BENZO[D]ISOTHIAZOL-3-YLAMINE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009982-A2 | ARYL-SUBSTITUTED BENZO[D]ISOTHIAZOL-3-YLAMINE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |