Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311755 | 1.00 | LMNA (0.48) | LMNAMAPTMDM2KDM4EMEN1 | |
| SCHEMBL7310907 | 0.83 | ALDH1A1 (0.50) | LMNAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL7310914 | 0.83 | ALDH1A1 (0.50) | LMNAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL9432247 | 0.82 | MAPT (0.41) | LMNAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL9432244 | 0.82 | MAPT (0.41) | LMNAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL3631342 | 0.77 | MAPT (0.54) | LMNAMAPTMDM2MEN1KMT2A | |
| SCHEMBL9519629 | 0.77 | MAPT (0.54) | LMNAMAPTMDM2MEN1KMT2A | |
| SCHEMBL4716443 | 0.76 | MEN1 (0.52) | LMNAKDM4EMEN1KMT2APKM | |
| SCHEMBL9893975 | 0.75 | MAPT (0.50) | LMNAMAPTMDM2MEN1KMT2A | |
| SCHEMBL9893976 | 0.75 | MAPT (0.50) | LMNAMAPTMDM2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |