Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311892 | 0.86 | MMP1 (0.45) | MAPTGAAL3MBTL1TDP1PPARA | |
| SCHEMBL7302773 | 0.80 | ALDH1A1 (0.45) | MAPTGAAL3MBTL1PPARAPPARG | |
| SCHEMBL11507588 | 0.69 | GAA (0.52) | GAALMNA | |
| SCHEMBL7617296 | 0.69 | MAPT (0.50) | MAPTL3MBTL1TDP1HPGDLMNA | |
| SCHEMBL21991844 | 0.69 | PPARA (0.56) | MAPTL3MBTL1PPARAPPARGHTR2A | |
| SCHEMBL11507140 | 0.69 | MIF (0.54) | MAPTL3MBTL1PPARAPPARGHTR2A | |
| SCHEMBL872958 | 0.69 | CXCL8 (0.67) | MAPTGAAL3MBTL1PPARAHTR2A | |
| SCHEMBL27477533 | 0.68 | FFAR1 (0.41) | MAPTGAAPPARAPPARGHTR2A | |
| Ammonia Solution, Strong SCHEMBL872909 | 0.68 | CHRM1 (0.65) | MAPTGAAL3MBTL1PPARAHTR2A | |
| SCHEMBL27894324 | 0.68 | MAPT (0.68) | MAPTGAAL3MBTL1TDP1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |