Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312420 | 0.88 | SLC6A4 (0.46) | SLC6A9PPARGPPARAHCAR2HTR1A | |
| SCHEMBL7310188 | 0.79 | LMNA (0.47) | L3MBTL1 | |
| SCHEMBL7310728 | 0.78 | SLC6A9 (0.49) | SLC6A9PPARGPPARAHTR1AALDH1A1 | |
| SCHEMBL5027210 | 0.76 | SLC6A9 (0.47) | SLC6A9PPARGPPARAHTR1AALDH1A1 | |
| SCHEMBL7409524 | 0.75 | SLC6A4 (0.49) | SLC6A9PPARGPPARAHTR1AMAPT | |
| SCHEMBL7318669 | 0.75 | SLC6A4 (0.49) | SLC6A9PPARGPPARAHTR1A | |
| Fumaric Acid SCHEMBL7312428 | 0.74 | SLC6A2 (0.54) | SLC6A9PPARGPPARAHTR1AALDH1A1 | |
| Maleic Acid SCHEMBL7312418 | 0.74 | SLC6A2 (0.54) | SLC6A9PPARGPPARAHTR1AALDH1A1 | |
| SCHEMBL7311168 | 0.73 | KMT2A (0.50) | SLC6A9HTR1APOLBMEN1KMT2A | |
| SCHEMBL7306077 | 0.72 | SLC6A4 (0.59) | SLC6A9HTR2AHTR2BSIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |