SCHEMBL7313767

SCHEMBL7313767

NC(=O)c1ncn2c1CN=C(c1ccccc1)c1cc(Cl)ccc1-2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRK1 P41145 4/20 0.55
PDE4D Q08499 1/20 0.55
GABRG2 P18507 7/20 0.54
GABRB3 P28472 7/20 0.54
GABRA5 P31644 7/20 0.54
GABRA2 P47869 7/20 0.54
GABRA1 P14867 5/20 0.54
GABRA3 P34903 5/20 0.54
GABRA6 Q16445 3/20 0.54
GABRA4 P48169 2/20 0.54
GABRB2 P47870 4/20 0.52
GABRP O00591 1/20 0.52
GABRD O14764 1/20 0.52
CACNA1F O60840 1/20 0.52
ALB P02768 1/20 0.52
GABRB1 P18505 1/20 0.52
AKR1C3 P42330 1/20 0.52
AKR1C2 P52895 1/20 0.52
GABRE P78334 1/20 0.52
CACNA1D Q01668 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6809989 0.91 OPRK1 (0.57) OPRK1PDE4DGABRG2GABRB3GABRA5
SCHEMBL7285884 0.88 GABRA3 (0.47) OPRK1PDE4DGABRG2GABRB3GABRA5
SCHEMBL7351846 0.88 GABRA5 (0.54) OPRK1PDE4DGABRG2GABRB3GABRA5
SCHEMBL7317878 0.87 GABRA2 (0.61) OPRK1PDE4DGABRG2GABRB3GABRA5
SCHEMBL7313317 0.87 GABRG2 (0.56) OPRK1PDE4DGABRG2GABRB3GABRA5
SCHEMBL19368454 0.85 GABRG2 (0.51) GABRG2GABRB3GABRA5GABRA2GABRA1
SCHEMBL639291 0.85 GABRG2 (0.74) GABRG2GABRB3GABRA5GABRA2GABRA1
SCHEMBL2841060 0.84 GABRG2 (0.76) GABRG2GABRB3GABRA5GABRA2GABRA1
SCHEMBL19368489 0.82 GABRG2 (0.49) GABRG2GABRB3GABRA5GABRA2GABRA1
SCHEMBL19368385 0.81 GABRG2 (0.59) GABRG2GABRB3GABRA5GABRA2GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4440685-A MUSCLE RELAXANTS, SEDATIVES, ANTICONVULSANTS HOFFMANN-LA ROCHE INC. (US) 1984-04-03 US disclosed
US-4425272-A ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1984-01-10 US disclosed
US-4401597-A INTERMEDIATES FOR ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVE AND ANXIOLYTICS HOFFMANN-LA ROCHE INC. (US) 1983-08-30 US disclosed
US-4390471-A INTERMEDIATES FOR IMIDOBENZODIAZEPINE AND ANALOGS HOFFMANN-LA ROCHE INC. (US) 1983-06-28 US disclosed
US-4377523-A Imidazodiazepines and processes therefor HOFFMANN-LA ROCHE INC. (US) 1983-03-22 US disclosed
US-4376075-A REACTION OF AN AMINODERIVATIVE THEREOF WITH AN ALDEHYDE HOFFMANN-LA ROCHE INC. (US) 1983-03-08 US disclosed
US-4376074-A ANTICONVULSANTS, MUSCLE RELAXANTS AND SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-03-08 US disclosed
US-4371468-A ANTICONVULSANTS, MUSCLE RELAXANTS, AND SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-02-01 US disclosed
US-4368157-A ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-01-11 US disclosed
US-4368158-A ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-01-11 US disclosed
US-4368159-A ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1983-01-11 US disclosed
US-4349476-A IMIDAZO/1,5-A//1,4) BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINE HOFFMANN-LA ROCHE INC. (US) 1982-09-14 US disclosed
US-4349477-A IMIPAZO/1,5-A//1,4/BENZO-, THIENO- OR PYRAZOLODIAZEPINES FROM 2-DIMORPHOLINOPHOSPHONATES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINES HOFFMANN-LA ROCHE INC. (US) 1982-09-14 US disclosed
US-4349475-A IMIDAZO/1,5-A//1,4/BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZOTHIENO-OR PYRAZOLODIAZEPINES HOFFMANN-LA ROCHE INC. (US) 1982-09-14 US disclosed
US-4347365-A ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES HOFFMANN-LA ROCHE INC. (US) 1982-08-31 US disclosed
US-4347364-A INTERMEDIATES THEREFOR HOFFMANN-LA ROCHE INC. (US) 1982-08-31 US disclosed
US-4307237-A ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS HOFFMANN-LA ROCHE INC. (US) 1981-12-22 US disclosed
US-4280957-A Imidazodiazepines and processes therefor HOFFMANN-LA ROCHE INC. (US) 1981-07-28 US disclosed