Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.37 |
| ▸ | MMP1 | P03956 | 8/20 | 0.37 |
| ▸ | MMP3 | P08254 | 8/20 | 0.37 |
| ▸ | MMP13 | P45452 | 7/20 | 0.37 |
| ▸ | MMP8 | P22894 | 6/20 | 0.37 |
| ▸ | MMP12 | P39900 | 6/20 | 0.37 |
| ▸ | MMP14 | P50281 | 6/20 | 0.37 |
| ▸ | MMP16 | P51512 | 6/20 | 0.37 |
| ▸ | MMP9 | P14780 | 6/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317836 | 0.93 | PLA2G2A (0.39) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7324134 | 0.92 | MMP1 (0.40) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7317682 | 0.85 | MMP2 (0.41) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7322659 | 0.82 | MMP2 (0.47) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7312473 | 0.82 | MCL1 (0.44) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7322414 | 0.81 | TP53 (0.45) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7322755 | 0.81 | MMP2 (0.40) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7325396 | 0.80 | MMP2 (0.41) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7318675 | 0.80 | MMP2 (0.45) | MMP2MMP1MMP3MMP13MMP8 | |
| SCHEMBL7324951 | 0.79 | CTRC (0.43) | MMP2MMP1MMP13MMP14MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |