Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304103 | 0.92 | SIGMAR1 (0.44) | SIGMAR1ITGB3ITGA2BF10 | |
| SCHEMBL6601180 | 0.91 | ITGB3 (0.45) | HTR1ASIGMAR1SLC6A4SLC6A2POLB | |
| SCHEMBL6604885 | 0.89 | ITGB3 (0.41) | HTR1ASIGMAR1DRD3SLC6A2POLB | |
| SCHEMBL6605691 | 0.89 | ITGB3 (0.51) | HTR1ASIGMAR1DRD3SLC6A4SLC6A2 | |
| SCHEMBL6603919 | 0.89 | ITGB3 (0.42) | HTR1ASIGMAR1SLC6A4SLC6A2POLB | |
| SCHEMBL6602885 | 0.89 | ITGB3 (0.42) | HTR1ASIGMAR1DRD3SLC6A4SLC6A2 | |
| SCHEMBL7314580 | 0.88 | ALDH1A1 (0.47) | SIGMAR1DRD3ITGB3ITGA2BF10 | |
| SCHEMBL6601430 | 0.87 | ITGB3 (0.43) | HTR1ASIGMAR1DRD3SLC6A4SLC6A2 | |
| SCHEMBL7314863 | 0.86 | SIGMAR1 (0.42) | HTR1ASIGMAR1ITGB3ITGA2BF10 | |
| SCHEMBL6605806 | 0.86 | ITGB3 (0.52) | HTR1ASIGMAR1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455529-B1 | OXAZOLIDIN-2-ONE DERIVATIVES; ANTICOAGULANTS; ANTIMETASTASIS, ANTICARCINOGENIC, ANTIISCHEMIC, AND ANTIINFLAMMATORY AGENTS; OSTEOPOROSIS, ARTERIOSCLEROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-09-24 | — | — | US | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |