Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | MMP16 | P51512 | 3/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323949 | 0.91 | EGFR (0.44) | EGFRERBB2GRK2MMP1MMP9 | |
| SCHEMBL7317410 | 0.90 | ALDH1A1 (0.47) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL7311138 | 0.89 | MMP13 (0.39) | EGFRERBB2MMP1MMP9MMP13 | |
| SCHEMBL7313804 | 0.85 | ALDH1A1 (0.45) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL7314232 | 0.85 | MMP2 (0.48) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL7324368 | 0.85 | CA1 (0.42) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL7323152 | 0.85 | EGFR (0.43) | EGFRERBB2GRK2MMP1MMP9 | |
| SCHEMBL7317696 | 0.84 | LMNA (0.42) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL7323459 | 0.83 | LMNA (0.41) | MMP1MMP9MMP13MMP2MMP3 | |
| SCHEMBL7324058 | 0.83 | NAMPT (0.49) | MMP1MMP9MMP13ADAM17ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |