Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.39 |
| ▸ | MMP9 | P14780 | 6/20 | 0.39 |
| ▸ | MMP2 | P08253 | 6/20 | 0.39 |
| ▸ | MMP14 | P50281 | 6/20 | 0.39 |
| ▸ | MMP8 | P22894 | 5/20 | 0.39 |
| ▸ | MMP12 | P39900 | 5/20 | 0.39 |
| ▸ | MMP16 | P51512 | 5/20 | 0.39 |
| ▸ | MMP1 | P03956 | 4/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316064 | 0.92 | MMP9 (0.43) | MMP13MMP9MMP2MMP14MMP8 | |
| SCHEMBL7325574 | 0.92 | MMP2 (0.40) | MMP13MMP9MMP2MMP14MMP8 | |
| SCHEMBL7324368 | 0.92 | CA1 (0.42) | MMP13MMP9MMP2MMP14MMP8 | |
| SCHEMBL7315402 | 0.89 | EGFR (0.45) | MMP13MMP9MMP2MMP14MMP8 | |
| SCHEMBL7317410 | 0.88 | ALDH1A1 (0.47) | MMP13MMP9MMP2MMP14MMP8 | |
| SCHEMBL7321847 | 0.84 | MMP13 (0.44) | MMP13MMP9MMP2MMP14MMP8 | |
| SCHEMBL7313804 | 0.84 | ALDH1A1 (0.45) | MMP13MMP9MMP2MMP14MMP8 | |
| SCHEMBL7314232 | 0.84 | MMP2 (0.48) | MMP13MMP9MMP2MMP14MMP8 | |
| SCHEMBL7324058 | 0.83 | NAMPT (0.49) | MMP13MMP9MMP1ADAM17ALDH1A1 | |
| SCHEMBL7316126 | 0.83 | TAS2R14 (0.45) | MMP13MMP9MMP2MMP14MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |