Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758080 | 0.87 | OPRM1 (0.42) | KIF11OPRM1OPRK1OPRL1PDK2 | |
| SCHEMBL7322102 | 0.85 | P2RX1 (0.46) | KIF11KDM4EPKMPDK2P2RX1 | |
| SCHEMBL7312957 | 0.82 | LMNA (0.43) | KIF11KDM4EPKMOPRM1OPRK1 | |
| SCHEMBL7320511 | 0.82 | PDK2 (0.47) | KIF11KDM4EOPRM1OPRK1OPRL1 | |
| SCHEMBL7322612 | 0.77 | CHRM3 (0.45) | OPRM1OPRK1OPRL1PDK2P2RX1 | |
| SCHEMBL7310248 | 0.77 | BCHE (0.39) | KIF11OPRM1OPRK1OPRL1PDK2 | |
| SCHEMBL11451560 | 0.76 | ELANE (0.44) | KIF11PDK2MDM2 | |
| SCHEMBL30838726 | 0.74 | PDK2 (0.44) | KIF11OPRM1OPRK1OPRL1PDK2 | |
| SCHEMBL28617342 | 0.74 | PDK2 (0.44) | KIF11OPRM1OPRK1OPRL1PDK2 | |
| SCHEMBL9644144 | 0.72 | PDK2 (0.42) | KIF11KDM4EPKMPDK2MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |