Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.54 |
| ▸ | HTR1D | P28221 | 6/20 | 0.51 |
| ▸ | HTR1B | P28222 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR1F | P30939 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671603 | 0.85 | HSD11B1 (0.56) | HSD11B1HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL4674039 | 0.85 | SLC6A4 (0.50) | HTR1BHTR1ASLC6A4 | |
| SCHEMBL7316005 | 0.83 | SLC6A4 (0.48) | HSD11B1HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL4670881 | 0.81 | HSD11B1 (0.46) | HSD11B1HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL18324763 | 0.79 | KDM4E (0.69) | HSD11B1HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL4673262 | 0.79 | HSD11B1 (0.64) | HSD11B1HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL4674153 | 0.78 | HSD11B1 (0.60) | HSD11B1HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL5340537 | 0.78 | HSD11B1 (0.68) | HSD11B1HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8109656 | 0.78 | OPRM1 (0.68) | HSD11B1HTR1BHTR1AOPRM1OPRK1 | |
| SCHEMBL4673535 | 0.77 | OPRM1 (0.56) | HSD11B1HTR1BHTR1AOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |