Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | HTR1D | P28221 | 3/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673257 | 0.84 | HSD11B1 (0.54) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL4671603 | 0.81 | HSD11B1 (0.56) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL18324838 | 0.80 | HSD11B1 (0.55) | HSD11B1OPRM1OPRL1SLC6A4HTR1A | |
| SCHEMBL7316014 | 0.79 | HSD11B1 (0.54) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL18324840 | 0.77 | HSD11B1 (0.65) | HSD11B1OPRM1OPRL1SLC6A4HTR1A | |
| SCHEMBL5340537 | 0.77 | HSD11B1 (0.68) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL8109656 | 0.77 | OPRM1 (0.68) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL4673535 | 0.76 | OPRM1 (0.56) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL18324763 | 0.76 | KDM4E (0.69) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL26912033 | 0.75 | PRKDC (0.60) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |