Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.59 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.56 |
| ▸ | CCR2 | P41597 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | HTR1D | P28221 | 2/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | HTR1F | P30939 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6347867 | 0.93 | HSD11B1 (0.76) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL6184605 | 0.90 | DRD2 (0.61) | HSD11B1OPRM1OPRL1SLC6A4CCR2 | |
| SCHEMBL18324763 | 0.89 | KDM4E (0.69) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL10922885 | 0.87 | HSD11B1 (0.66) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL4769253 | 0.85 | OPRM1 (0.63) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL1121919 | 0.85 | HTR1D (0.68) | HSD11B1CCR2HTR1AHTR1DHTR1B | |
| SCHEMBL6165281 | 0.84 | HSD11B1 (0.58) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL8556742 | 0.83 | HSD11B1 (0.61) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| Bicarbonate SCHEMBL7460768 | 0.83 | HSD11B1 (0.65) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL4674153 | 0.83 | HSD11B1 (0.60) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173045-B2 | 4-aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2007-02-06 | — | — | US | claimed |
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2005-11-03 | — | — | US | claimed |
| EP-1562891-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-08-17 | — | — | EP | claimed |
| WO-2004043899-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | claimed |
| US-6509340-B1 | These preparations can be employed as medicaments in human and veterinary medicine. Possible excipients are organic or inorganic substances which are suitable for enteral (e.g. oral) on the central nervous system. | MERCK PATENTGESELLSCHAFT (DE) | 2003-01-21 | — | — | US | claimed |
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| US-7173045-B2 | 4-aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2007-02-06 | — | — | US | disclosed |
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2005-11-03 | — | — | US | disclosed |
| EP-1562891-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-08-17 | — | — | EP | disclosed |
| US-20050176730-A1 | Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT 1B/1D ligands | MERCK PATENT GMBH (DE) | 2005-08-11 | — | — | US | disclosed |
| WO-2004043899-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |
| US-20030064995-A1 | Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands | MERCK PATENT GMBH (DE) | 2003-04-03 | — | — | US | disclosed |
| US-6509340-B1 | These preparations can be employed as medicaments in human and veterinary medicine. Possible excipients are organic or inorganic substances which are suitable for enteral (e.g. oral) on the central nervous system. | MERCK PATENTGESELLSCHAFT (DE) | 2003-01-21 | — | — | US | disclosed |
| CN-1336924-A | Amide and urea derivatives as 5-HT reuptake inhibitors and at 5-HT 1B/1D ligands | MERCK PATENT GMBH (DE) | 2002-02-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | HNMT, PNMT, INMT | HSD11B1 3086/4885OPRM1 69/4885OPRK1 190/4885 |
| US-20050176730-A1 | Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT 1B/1D ligands | HTR1B, HTR1D, HTR1A | HSD11B1 2163/4885OPRM1 23/4885OPRK1 43/4885 |
| US-20030064995-A1 | Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands | HTR5A, HTR1B, HTR1A | HSD11B1 3340/4885OPRM1 17/4885OPRK1 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.