Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 8/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 5/20 | 0.42 |
| ▸ | MMP9 | P14780 | 5/20 | 0.42 |
| ▸ | MMP13 | P45452 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314645 | 0.94 | MMP1 (0.46) | KEAP1NFE2L2NAMPTHTR1ADRD2 | |
| SCHEMBL7316579 | 0.83 | KDM4E (0.44) | NAMPTMMP1MMP9MMP13ALDH1A1 | |
| SCHEMBL7311156 | 0.83 | KDM4E (0.44) | NAMPTMMP1MMP9MMP13ALDH1A1 | |
| SCHEMBL7322032 | 0.80 | MMP13 (0.40) | NAMPTMMP1MMP9MMP13ALDH1A1 | |
| SCHEMBL7316350 | 0.80 | MMP1 (0.42) | KEAP1NFE2L2MMP1MMP9MMP13 | |
| SCHEMBL7318336 | 0.79 | KDM4E (0.41) | NAMPTMMP1MMP9MMP13ALDH1A1 | |
| SCHEMBL7320602 | 0.79 | MMP9 (0.47) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7323468 | 0.78 | MMP1 (0.46) | KEAP1NFE2L2NAMPTMMP1MMP9 | |
| SCHEMBL7325340 | 0.78 | HCAR2 (0.47) | MMP1MMP9MMP13ALDH1A1ADAM17 | |
| SCHEMBL7317521 | 0.78 | MMP13 (0.41) | NAMPTMMP1MMP9MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |