Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MMP13 | P45452 | 4/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 9/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318043 | 0.94 | KEAP1 (0.46) | MMP1MMP9MMP13ADAM17NAMPT | |
| SCHEMBL7322032 | 0.87 | MMP13 (0.40) | MMP1MMP9MMP13ADAM17NAMPT | |
| SCHEMBL7317521 | 0.84 | MMP13 (0.41) | MMP1MMP9MMP13ADAM17NAMPT | |
| SCHEMBL7316579 | 0.83 | KDM4E (0.44) | MMP1MMP9MMP13ADAM17NAMPT | |
| SCHEMBL7322262 | 0.83 | LMNA (0.43) | MMP1MMP9MMP13ADAM17NAMPT | |
| SCHEMBL7316215 | 0.81 | MMP13 (0.41) | MMP1MMP9MMP13ADAM17NAMPT | |
| SCHEMBL7313726 | 0.80 | MMP1 (0.42) | MMP1MMP9MMP13ADAM17SMN1; SMN2 | |
| SCHEMBL7320602 | 0.79 | MMP9 (0.47) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7320885 | 0.78 | MMP1 (0.44) | MMP1MMP9MMP13ADAM17NAMPT | |
| SCHEMBL7319136 | 0.77 | SMN1; SMN2 (0.40) | MMP1MMP9MMP13ADAM17NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |