Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 8/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.52 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740321 | 0.90 | SLC6A9 (0.57) | SLC6A9SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL4660 | 0.84 | HTR1A (0.46) | SLC6A9SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL3802 | 0.84 | OPRM1 (0.48) | SLC6A9SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL4740057 | 0.84 | SLC6A9 (0.48) | SLC6A9SLC6A4HRH3CYP1A2TSHR | |
| SCHEMBL10539 | 0.83 | SLC7A5 (0.52) | SLC6A9SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL4736090 | 0.82 | SLC6A9 (0.50) | SLC6A9SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL4738511 | 0.82 | SLC6A9 (0.50) | SLC6A9SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL7306077 | 0.82 | SLC6A4 (0.59) | SLC6A9SLC6A4HRH3SLC6A2SLC6A3 | |
| SCHEMBL9500936 | 0.81 | SLC6A9 (0.57) | SLC6A9 | |
| SCHEMBL11350917 | 0.81 | ALDH1A1 (0.45) | SLC6A9KMT2ALMNAOPRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4584404-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1986-04-22 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |