Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.55 |
| ▸ | F2 | P00734 | 2/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.54 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.54 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8696501 | 0.80 | CYP2C9 (0.49) | ITGB3ITGA2BALOX15ALDH1A1MAPT | |
| SCHEMBL7318615 | 0.76 | OPRD1 (0.41) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7347645 | 0.73 | F2 (0.58) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL2403330 | 0.73 | F2 (1.00) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL10187743 | 0.73 | HSD17B10 (0.49) | ALOX15NPC1ALDH1A1LMNAMAPT | |
| SCHEMBL7315288 | 0.71 | ITGB3 (0.68) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7782353 | 0.70 | ITGB3 (1.00) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL6705795 | 0.70 | LMNA (0.55) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7317414 | 0.70 | OPRD1 (0.47) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7439185 | 0.70 | ITGB3 (0.52) | ITGB3ITGA2BF2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843948-A | Piperazinophenyl- and piperazinophenyloxycarboxylic acid derivatives, and processes and intermediates for their preparation and pharmaceutical compositions comprising them | SOLVAY PHARMACEUTICALS GMBH (DE) | 1998-12-01 | — | — | US | claimed |
| US-5843948-A | Piperazinophenyl- and piperazinophenyloxycarboxylic acid derivatives, and processes and intermediates for their preparation and pharmaceutical compositions comprising them | SOLVAY PHARMACEUTICALS GMBH (DE) | 1998-12-01 | — | — | US | disclosed |