Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.68 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.68 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.51 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.51 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.51 |
| ▸ | ME2 | P23368 | 1/20 | 0.49 |
| ▸ | ME1 | P48163 | 1/20 | 0.49 |
| ▸ | ME3 | Q16798 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7782353 | 0.81 | ITGB3 (1.00) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL8696504 | 0.81 | HRH3 (0.51) | ITGB3ITGA2BME2ME1ME3 | |
| SCHEMBL7316277 | 0.78 | ITGB3 (0.70) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL2403330 | 0.71 | F2 (1.00) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7318604 | 0.71 | ITGB3 (0.55) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7075132 | 0.71 | TPSAB1 (0.68) | F2NPC1RAB9A | |
| SCHEMBL6482397 | 0.71 | MAPT (0.54) | MAPK1NPC1RAB9A | |
| SCHEMBL8407796 | 0.69 | ITGB3 (0.45) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL9030446 | 0.69 | MRGPRX1 (0.57) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7274743 | 0.68 | ITGB3 (0.74) | ITGB3ITGA2BF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843948-A | Piperazinophenyl- and piperazinophenyloxycarboxylic acid derivatives, and processes and intermediates for their preparation and pharmaceutical compositions comprising them | SOLVAY PHARMACEUTICALS GMBH (DE) | 1998-12-01 | — | — | US | disclosed |