Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 5/20 | 0.56 |
| ▸ | PPARA | Q07869 | 5/20 | 0.56 |
| ▸ | CNR1 | P21554 | 2/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.48 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.48 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.48 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045802 | 0.81 | DRD2 (0.58) | GAAMEN1KMT2AL3MBTL1 | |
| SCHEMBL28079976 | 0.72 | L3MBTL1 (0.56) | TAAR1CNR1ALDH1A1GAAEPHX2 | |
| Oxalic Acid SCHEMBL7318660 | 0.71 | PPARG (0.66) | TAAR1PPARGPPARA | |
| SCHEMBL1101359 | 0.70 | GAA (0.53) | TAAR1ALDH1A1GAAMEN1LMNA | |
| SCHEMBL22834239 | 0.70 | CNR1 (1.00) | CNR1ALDH1A1TP53MEN1LMNA | |
| SCHEMBL2170220 | 0.69 | TRPV1 (0.64) | CNR1ALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL16936556 | 0.68 | CNR1 (0.60) | TAAR1CNR1CNR2ALDH1A1GAA | |
| SCHEMBL10812127 | 0.68 | HTR2A (0.60) | TAAR1CNR1ALDH1A1TP53GAA | |
| SCHEMBL4897614 | 0.68 | NPC1 (0.58) | CNR1ALDH1A1GAAEPHX2MAPT | |
| SCHEMBL27656774 | 0.68 | KMT2A (0.68) | TAAR1PPARGPPARAPLAAT3PLAAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |