Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1101359 | 0.88 | GAA (0.53) | DRD2DRD4DRD3SIGMAR1MEN1 | |
| Oxalic Acid SCHEMBL7318666 | 0.81 | TAAR1 (0.58) | MEN1KMT2AL3MBTL1GAA | |
| SCHEMBL321109 | 0.78 | ALDH1A1 (0.45) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL3227303 | 0.78 | LTA4H (0.47) | DRD2DRD4DRD3SIGMAR1KMT2A | |
| SCHEMBL31438227 | 0.78 | SIGMAR1 (0.59) | DRD2DRD4DRD3SIGMAR1MEN1 | |
| SCHEMBL5306298 | 0.77 | HTR2A (0.51) | SIGMAR1MEN1KMT2ABCHEHPGD | |
| SCHEMBL8371908 | 0.77 | MEN1 (0.49) | DRD2DRD4DRD3SIGMAR1MEN1 | |
| SCHEMBL10693909 | 0.76 | SIGMAR1 (0.57) | DRD2DRD4DRD3SIGMAR1MEN1 | |
| SCHEMBL3229694 | 0.76 | LTA4H (0.47) | DRD2DRD3SIGMAR1HPGD | |
| Hydrochloric Acid SCHEMBL10766746 | 0.75 | MEN1 (0.51) | DRD2DRD4DRD3SIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895558-B2 | Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders | GREEN CROSS CORPORATION (KR) | 2014-11-25 | — | — | US | disclosed |
| US-8835436-B2 | Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same | GREEN CROSS CORPORATION (KR) | 2014-09-16 | — | — | US | disclosed |
| US-8785453-B2 | Arylpiperazine-containing purine derivatives and uses thereof | GREEN CROSS CORPORATION (KR) | 2014-07-22 | — | — | US | disclosed |
| US-20120232090-A1 | ARYLPIPERAZINE-CONTAINING PURINE DERIVATIVES AND USES THEREOF | GREEN CROSS CORPORATION (KR) | 2012-09-13 | — | — | US | disclosed |
| US-20120115881-A1 | NOVEL ARYLPIPERAZINE-CONTAINING IMIDAZOLE 4-CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | GREEN CROSS CORPORATION (KR) | 2012-05-10 | — | — | US | disclosed |
| US-20110178091-A1 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | GREEN CROSS CORPORATION (KR) | 2011-07-21 | — | — | US | disclosed |
| WO-2011059207-A2 | ARYLPIPERAZINE-CONTAINING PURINE DERIVATIVES AND USES THEREOF | GREEN CROSS CORPORATION (KR) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011005052-A2 | NOVEL ARYLPIPERAZINE-CONTAINING IMIDAZOLE 4-CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | GREEN GROSS CORPORATION (KR) | 2011-01-13 | — | — | WO | disclosed |
| WO-2010038948-A2 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | GREEN CROSS CORPORATION (KR) | 2010-04-08 | — | — | WO | disclosed |
| US-20020151543-A1 | Compositions and methods employing R (-) fluoxetine and other active ingredients | SEPRACOR INC. | 2002-10-17 | — | — | US | disclosed |
| WO-2000024399-A1 | COMPOSITIONS AND METHODS EMPLOYING R(-) FLUOXETINE AND OTHER ACTIVE INGREDIENTS | SEPRACOR INC. (US) | 2000-05-04 | — | — | WO | disclosed |
| WO-1999061014-A2 | COMPOSITIONS AND METHODS EMPLOYING R(-) FLUOXETINE AND OTHER ACTIVE INGREDIENTS | SEPRACOR INC. (US) | 1999-12-02 | — | — | WO | disclosed |
| US-4895845-A | RESERPINE AND TRAZODONE, BUPROPION OR FLUOXETINE ANTIDEPRESSANT | SEED JOHN C (US) | 1990-01-23 | — | — | US | disclosed |
| US-4895845-A | RESERPINE AND TRAZODONE, BUPROPION OR FLUOXETINE ANTIDEPRESSANT | SEED JOHN C (US) | 1990-01-23 | — | — | US | disclosed |
| US-4584404-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1986-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178091-A1 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | NPY5R, TPH2, MC5R | DRD2 347/4885DRD4 425/4885DRD3 517/4885 |
| US-20120232090-A1 | ARYLPIPERAZINE-CONTAINING PURINE DERIVATIVES AND USES THEREOF | ADORA2A, P2RX5, PNP | DRD2 137/4885DRD4 174/4885DRD3 363/4885 |
| US-20120115881-A1 | NOVEL ARYLPIPERAZINE-CONTAINING IMIDAZOLE 4-CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | HTR2C, HTR5A, HTR2A | DRD2 108/4885DRD4 163/4885DRD3 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.