Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | LCAT | P04180 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2306880 | 0.85 | NOTUM (0.34) | HRH3 | |
| SCHEMBL731968 | 0.82 | LMNA (0.42) | — | |
| SCHEMBL1945899 | 0.82 | PDE10A (0.34) | PDE10AHRH3MAPT | |
| SCHEMBL733359 | 0.82 | PDE10A (0.34) | PDE10AHRH3MAPT | |
| SCHEMBL4229828 | 0.78 | HRH3 (0.34) | SMOHRH3MDM2LCATMAPT | |
| SCHEMBL733745 | 0.73 | HRH3 (0.35) | SMOHRH3 | |
| SCHEMBL734283 | 0.71 | SCD5 (0.41) | MAPT | |
| SCHEMBL733541 | 0.69 | MC4R (0.49) | — | |
| SCHEMBL733540 | 0.69 | MC4R (0.49) | — | |
| SCHEMBL733977 | 0.69 | MC4R (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138188-B2 | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines | PFIZER INC. (US) | 2012-03-20 | — | — | US | disclosed |