Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6660888 | 0.79 | MAPT (0.47) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL6267555 | 0.78 | ADAM17 (0.48) | ADAM17NPC1RAB9AMAPTMMP13 | |
| SCHEMBL6661137 | 0.77 | ALDH1A1 (0.58) | ADAM17MMP13MMP9MMP1PPARG | |
| SCHEMBL6787275 | 0.77 | ADAM17 (0.62) | ADAM17MAPTMMP13MMP9MMP1 | |
| SCHEMBL6657126 | 0.74 | ADAM17 (0.74) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6655282 | 0.71 | PTGS2 (0.57) | ADAM17 | |
| SCHEMBL6787497 | 0.70 | ADAM17 (0.44) | ADAM17MAPTMMP13MMP9MMP1 | |
| SCHEMBL4555336 | 0.70 | L3MBTL1 (0.57) | RAB9ASMN1; SMN2 | |
| SCHEMBL6657581 | 0.68 | ADAM17 (0.78) | ADAM17MMP13MMP9MMP1PPARG | |
| SCHEMBL6655284 | 0.68 | ADAM17 (0.51) | ADAM17MMP13MMP9MMP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340691-B1 | TREATMENT OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-01-22 | — | — | US | disclosed |