Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | GRK2 | P25098 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | AOC2 | O75106 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353455 | 0.80 | HDAC3 (0.49) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL10625333 | 0.79 | CYP3A4 (0.58) | KMT2ALMNAMAPTTDP1 | |
| SCHEMBL10559260 | 0.77 | CA12 (0.57) | KMT2APOLBALDH1A1LMNAMEN1 | |
| SCHEMBL8775491 | 0.74 | CHRM2 (0.53) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7325551 | 0.74 | LMNA (0.53) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7316169 | 0.73 | KMT2A (0.69) | KMT2APOLBAOC2ALDH1A1MEN1 | |
| SCHEMBL135357 | 0.73 | PGR (0.52) | KMT2AADRA2BALDH1A1LMNAMMP2 | |
| SCHEMBL8823315 | 0.73 | PGR (0.52) | KMT2AADRA2BALDH1A1LMNAMMP2 | |
| SCHEMBL8381806 | 0.73 | MAPT (0.44) | POLBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7268544 | 0.73 | CES2 (0.43) | KMT2AHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220044-A2 | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-04-29 | — | — | EP | claimed |
| US-5246928-A | Cardiovascular disorders | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-21 | — | — | US | disclosed |
| EP-0260102-B1 | CHEMICAL PROCESS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |
| US-5066653-A | Cardiovascular disorders; bronchodilators; phosphodiesterase inhibitors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |
| US-4906628-A | N-phenylpyridone type III phosphodiesterases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-03-06 | — | — | US | disclosed |
| US-4782159-A | Process for preparing beta-methyl-gamma-oxo-4-(4-oxo-1(4H)-pyridinyl) derivative of benzene butanoic acid | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-11-01 | — | — | US | disclosed |
| US-4782159-A | Process for preparing beta-methyl-gamma-oxo-4-(4-oxo-1(4H)-pyridinyl) derivative of benzene butanoic acid | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-11-01 | — | — | US | disclosed |
| EP-0260102-A2 | Chemical process | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-03-16 | — | — | EP | disclosed |
| EP-0260102-A2 | Chemical process | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-03-16 | — | — | EP | disclosed |
| EP-0220044-A2 | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-04-29 | — | — | EP | disclosed |