Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.57 |
| ▸ | CTSE | P14091 | 7/20 | 0.57 |
| ▸ | CTSD | P07339 | 6/20 | 0.56 |
| ▸ | PGA5 | P0DJD9 | 4/20 | 0.56 |
| ▸ | PGC | P20142 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320800 | 0.82 | REN (0.77) | RENCTSECTSDPGA5PGC | |
| SCHEMBL7436682 | 0.79 | REN (0.73) | REN | |
| SCHEMBL7322193 | 0.78 | REN (0.38) | RENCTSECTSDPGA5 | |
| SCHEMBL7316049 | 0.76 | REN (0.42) | REN | |
| SCHEMBL7311937 | 0.76 | REN (0.39) | REN | |
| SCHEMBL7385303 | 0.72 | REN (0.47) | REN | |
| SCHEMBL7323158 | 0.72 | REN (0.43) | REN | |
| SCHEMBL7403552 | 0.72 | REN (0.44) | REN | |
| SCHEMBL7299338 | 0.71 | REN (0.46) | RENPGC | |
| SCHEMBL9523860 | 0.71 | REN (0.46) | RENPGC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198426-A | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0380805-A1 | Renin inhibitors containing C-terminal dihydroxy amides | WARNER-LAMBERT COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |
| WO-1990007521-A1 | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |