Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458635 | 0.84 | REN (1.00) | REN | |
| SCHEMBL9322087 | 0.83 | REN (0.54) | REN | |
| SCHEMBL9458632 | 0.81 | REN (0.58) | REN | |
| SCHEMBL7320803 | 0.79 | REN (0.57) | REN | |
| SCHEMBL9388320 | 0.72 | REN (0.48) | REN | |
| SCHEMBL8955003 | 0.71 | REN (0.66) | REN | |
| SCHEMBL9556735 | 0.71 | REN (0.50) | REN | |
| SCHEMBL9322207 | 0.71 | REN (0.67) | REN | |
| SCHEMBL8904006 | 0.70 | REN (0.69) | REN | |
| SCHEMBL7392080 | 0.70 | REN (0.50) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634175-B1 | Pharmaceutical combination, containing a renin-angiotensin-system inhibitor and an endothelin antagonist | HOFFMANN LA ROCHE (CH) | 2001-01-10 | — | — | EP | disclosed |
| EP-0892783-A1 | CARBOXYLIC ACID DERIVATIVES WITH AN AGGREGATION-INHIBITING ACTION | Dr. Karl Thomae GmbH (DE) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997037975-A1 | CARBOXYLIC ACID DERIVATIVES WITH AN AGGREGATION-INHIBITING ACTION | DR. KARL THOMAE GMBH (DE) | 1997-10-16 | — | — | WO | disclosed |
| EP-0581899-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 1S-(1R*, 2S*, 3R*)]-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N- (1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE | WARNER-LAMBERT COMPANY (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5268483-A | Process for the preparation of an L-alanine compound | WARNER-LAMBERT COMPANY (US) | 1993-12-07 | — | — | US | disclosed |
| US-5220031-A | Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| US-5220031-A | Process for the preparation of [1S-(1R*,2S*3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| WO-1992018486-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [1S-(1R*, 2S*, 3R*)]-N-(4-(MORPHOLINYLSULFONYL)-L-PHENYLALANYL-3-(2-AMINO-4-THIAZOLYL)-N-[(1-CYCLOHEXYLMETHYL)-2,3-DIHYDROXY-5-METHYLHEXYL]-L-ALANINAMIDE | WARNER-LAMBERT COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |
| US-5089616-A | Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | disclosed |
| US-5089616-A | Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | disclosed |