Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325119 | 0.86 | MMP9 (0.39) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7351590 | 0.85 | MMP9 (0.41) | MMP9MMP13MMP1ADAM17MMP3 | |
| SCHEMBL7317531 | 0.77 | NAMPT (0.47) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL7321295 | 0.77 | MMP9 (0.49) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7317121 | 0.71 | LMNA (0.42) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7323861 | 0.71 | MMP2 (0.41) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7322141 | 0.71 | MMP9 (0.45) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7322044 | 0.69 | NAMPT (0.47) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL7323459 | 0.69 | LMNA (0.41) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7324868 | 0.69 | MMP9 (0.50) | MMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |