Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MMP16 | P51512 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320836 | 0.86 | MMP9 (0.39) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL7351590 | 0.80 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1MMP3 | |
| SCHEMBL7322465 | 0.79 | MMP2 (0.37) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL7316225 | 0.77 | NAMPT (0.47) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL7317121 | 0.71 | LMNA (0.42) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL7323861 | 0.69 | MMP2 (0.41) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL7322141 | 0.69 | MMP9 (0.45) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL7321207 | 0.68 | ALDH1A1 (0.45) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL7323004 | 0.68 | RAPGEF4 (0.48) | MMP9MMP13MMP2ALDH1A1LMNA | |
| SCHEMBL7323459 | 0.67 | LMNA (0.41) | MMP9MMP13ADAM17MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |