Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.65 |
| ▸ | ACLY | P53396 | 2/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23200290 | 0.92 | CYP2C9 (0.76) | CYP2C9CYP2C19FFAR4ACLYMCL1 | |
| SCHEMBL7322109 | 0.90 | METAP2 (0.73) | CYP2C9CYP2C19FFAR4POLBCYP1A2 | |
| SCHEMBL12201452 | 0.89 | ACLY (0.74) | CYP2C9CYP2C19ACLYMCL1POLB | |
| SCHEMBL12200959 | 0.86 | CYP2C9 (0.61) | CYP2C9CYP2C19FFAR4ACLYMCL1 | |
| SCHEMBL12200967 | 0.84 | CYP2C9 (0.76) | CYP2C9CYP2C19FFAR4MCL1POLB | |
| SCHEMBL12768020 | 0.83 | FFAR4 (0.81) | FFAR4ALDH1A1KDM4EKEAP1NFE2L2 | |
| SCHEMBL25140563 | 0.83 | AKR1C3 (0.64) | CYP2C9CYP2C19ACLYPOLBMETAP2 | |
| SCHEMBL5955445 | 0.83 | CYP2C9 (0.84) | CYP2C9CYP2C19FFAR4POLBCYP1A2 | |
| SCHEMBL30486834 | 0.82 | LMNA (0.70) | POLBALDH1A1KDM4EKEAP1NFE2L2 | |
| SCHEMBL2477690 | 0.82 | LMNA (0.70) | POLBALDH1A1KDM4EKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| CN-1240429-A | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors | AMERICAN CYANAMID CO (US) | 2000-01-05 | — | — | CN | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |