Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317403 | 0.93 | METAP2 (0.48) | METAP2MEN1KMT2AFFAR4GABRG2 | |
| SCHEMBL7325564 | 0.91 | METAP2 (0.49) | METAP2MEN1KMT2AFFAR4GABRG2 | |
| SCHEMBL7318667 | 0.90 | METAP2 (0.45) | METAP2MEN1KMT2AGAAMTNR1A | |
| SCHEMBL7325546 | 0.90 | METAP2 (0.56) | METAP2MEN1KMT2AALDH1A1MMP13 | |
| SCHEMBL7313454 | 0.90 | ACLY (0.51) | METAP2MEN1KMT2AFFAR4GAA | |
| SCHEMBL7315641 | 0.88 | METAP2 (0.54) | METAP2MEN1KMT2AFFAR4GABRG2 | |
| SCHEMBL7324937 | 0.88 | METAP2 (0.54) | METAP2ALDH1A1MMP1MMP13HPGD | |
| SCHEMBL7317721 | 0.88 | METAP2 (0.57) | METAP2MEN1KMT2AFFAR4GABRG2 | |
| SCHEMBL7317673 | 0.88 | METAP2 (0.43) | METAP2MEN1KMT2AGAAMTNR1A | |
| SCHEMBL7325389 | 0.88 | METAP2 (0.43) | METAP2MEN1KMT2AFFAR4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |