Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311131 | 0.93 | FFAR4 (0.44) | METAP2FFAR4MMP1MMP13MEN1 | |
| SCHEMBL7322650 | 0.91 | METAP2 (0.58) | METAP2FFAR4MMP1MMP13MEN1 | |
| SCHEMBL7318667 | 0.87 | METAP2 (0.45) | METAP2MMP1MMP13MEN1KMT2A | |
| SCHEMBL7315641 | 0.85 | METAP2 (0.54) | METAP2FFAR4MMP1MMP13MEN1 | |
| SCHEMBL7317403 | 0.84 | METAP2 (0.48) | METAP2FFAR4MMP1MMP13MEN1 | |
| SCHEMBL7317721 | 0.83 | METAP2 (0.57) | METAP2FFAR4MEN1KMT2AGAA | |
| SCHEMBL7313454 | 0.83 | ACLY (0.51) | METAP2FFAR4MEN1KMT2AGAA | |
| SCHEMBL7315387 | 0.82 | FFAR4 (0.44) | METAP2FFAR4MMP1MMP13MEN1 | |
| SCHEMBL7325546 | 0.81 | METAP2 (0.56) | METAP2MMP13MEN1KMT2AMMP9 | |
| SCHEMBL7313794 | 0.80 | MTNR1A (0.42) | MMP1MMP13MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |