Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316128 | 0.90 | MEN1 (0.48) | METAP2MMP9MMP13ADAM17MEN1 | |
| SCHEMBL7324937 | 0.90 | METAP2 (0.54) | METAP2MMP9MMP13ADAM17ALDH1A1 | |
| SCHEMBL7322650 | 0.90 | METAP2 (0.58) | METAP2MMP13MEN1KMT2AALDH1A1 | |
| SCHEMBL7316879 | 0.84 | METAP2 (0.57) | METAP2MEN1KMT2APKMALDH1A1 | |
| SCHEMBL7317403 | 0.83 | METAP2 (0.48) | METAP2MMP13MEN1KMT2APKM | |
| SCHEMBL7322578 | 0.82 | MMP13 (0.45) | METAP2MMP9MMP13ADAM17ALDH1A1 | |
| SCHEMBL7325564 | 0.81 | METAP2 (0.49) | METAP2MMP9MMP13ADAM17MEN1 | |
| SCHEMBL7318667 | 0.80 | METAP2 (0.45) | METAP2MMP9MMP13ADAM17MEN1 | |
| SCHEMBL7313454 | 0.80 | ACLY (0.51) | METAP2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7315641 | 0.79 | METAP2 (0.54) | METAP2MMP9MMP13ADAM17MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |