Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | WDR5 | P61964 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 6/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 6/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322578 | 0.92 | MMP13 (0.45) | METAP2MMP13ADAM17MMP9WDR5 | |
| SCHEMBL7325546 | 0.90 | METAP2 (0.56) | METAP2MMP13ADAM17MMP9MCL1 | |
| SCHEMBL7322650 | 0.88 | METAP2 (0.58) | METAP2MMP13MCL1ALDH1A1HPGD | |
| SCHEMBL7316879 | 0.82 | METAP2 (0.57) | METAP2ALDH1A1HPGDHSD17B10FABP4 | |
| SCHEMBL7317403 | 0.82 | METAP2 (0.48) | METAP2MMP13ALDH1A1MMP1 | |
| SCHEMBL7316128 | 0.81 | MEN1 (0.48) | METAP2MMP13ADAM17MMP9MCL1 | |
| SCHEMBL7325564 | 0.80 | METAP2 (0.49) | METAP2MMP13ADAM17MMP9ALDH1A1 | |
| SCHEMBL7314649 | 0.79 | MEN1 (0.38) | METAP2WDR5MCL1ALDH1A1 | |
| SCHEMBL7318667 | 0.79 | METAP2 (0.45) | METAP2MMP13ADAM17MMP9MCL1 | |
| SCHEMBL7317721 | 0.79 | METAP2 (0.57) | METAP2MCL1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |