SCHEMBL7323342

SCHEMBL7323342

CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](CO)Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.60
MAPK1 P28482 1/20 0.60
CYP1A2 P05177 2/20 0.58
CYP2D6 P10635 2/20 0.58
CYP2C9 P11712 2/20 0.58
CYP2C19 P33261 2/20 0.58
ALDH1A1 P00352 2/20 0.58
TSHR P16473 2/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
CTSD P07339 1/20 0.58
CTRB1 P17538 2/20 0.57
CASP3 P42574 1/20 0.55
CTSL P07711 4/20 0.54
CTSK P43235 3/20 0.54
CTSS P25774 2/20 0.53
CTSB P07858 1/20 0.53
ECE1 P42892 2/20 0.53
CA2 P00918 1/20 0.53
CA5A P35218 1/20 0.53
MME P08473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10084557 0.95 CYP3A4 (0.55) CYP3A4MAPK1CYP1A2CYP2D6CYP2C9
SCHEMBL30601624 0.93 CYP3A4 (0.55) CYP3A4MAPK1CYP1A2CYP2D6CYP2C9
SCHEMBL623817 0.92 CTSD (0.53) CYP3A4MAPK1CYP1A2CYP2D6CYP2C9
SCHEMBL623600 0.92 CTSD (0.52) CYP3A4MAPK1CYP1A2CYP2D6CYP2C9
SCHEMBL623599 0.92 CTSD (0.52) CYP3A4MAPK1CYP1A2CYP2D6CYP2C9
SCHEMBL623598 0.92 CTSD (0.52) CYP3A4MAPK1CYP1A2CYP2D6CYP2C9
SCHEMBL10084883 0.89 ITGB3 (0.51) CYP3A4MAPK1CYP1A2CYP2D6CYP2C9
SCHEMBL8536240 0.87 CASP3 (0.58) CYP3A4CTSDCTRB1CASP3CTSL
SCHEMBL7269151 0.86 ALDH1A1 (0.60) ALDH1A1CTSDCASP3CTSLCTSK
SCHEMBL8742453 0.86 CYP3A4 (0.61) CYP3A4MAPK1CYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1123919-A1 PROCESS FOR PRODUCING PEPTIDYL ALDEHYDES Senju Pharmaceutical Co., Ltd. (JP) 2001-08-16 EP disclosed
WO-1998038990-A1 METHOD OF TREATING TRAUMA ASSOCIATED WITH BRAIN, SPINAL CORD OR PERIPHERAL NERVE INJURY USING CARBOBENZYLOXY N-PROTECTED DI- AND TRIPEPTIDE PHENYLALANINALS HOECHST MARION ROUSSEL, INC. (US) 1998-09-11 WO disclosed
EP-0594656-A1 4-AMINO-3-HYDROXYCARBOXYLIC ACID DERIVATIVES SANDOZ LTD. (CH) 1994-05-04 EP disclosed
WO-1993001166-A1 4-AMINO-3-HYDROXYCARBOXYLIC ACID DERIVATIVES SANDOZ LTD. (CH) 1993-01-21 WO disclosed