Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.69 |
| ▸ | CTSB | P07858 | 5/20 | 0.51 |
| ▸ | CTSL | P07711 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 5/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325702 | 0.90 | ELANE (0.61) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL7331321 | 0.89 | ELANE (0.56) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL7332393 | 0.89 | ELANE (0.56) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL7303462 | 0.88 | ELANE (0.57) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL27278810 | 0.88 | ELANE (0.57) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL7308079 | 0.81 | ELANE (0.53) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL7330793 | 0.81 | ELANE (0.49) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL7325639 | 0.81 | CTSL (0.57) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL7431398 | 0.80 | ELANE (0.51) | ELANECTSBCTSLCTSSCTSK | |
| SCHEMBL9725896 | 0.80 | CTSK (0.53) | ELANECTSBCTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221665-A | N-substituted amides | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1993-06-22 | — | — | US | disclosed |
| US-5166154-A | Inhibitors of human neutrophil elastase | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0369391-A2 | N-substituted amides | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1990-05-23 | — | — | EP | disclosed |