Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10462119 | 0.86 | HPGD (0.52) | HPGDMAPTPOLBTSHRHSD17B10 | |
| SCHEMBL22418936 | 0.83 | ALDH1A1 (0.54) | MAPTNPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL7322618 | 0.82 | SIRT6 (0.53) | HPGDMAPTPOLBTSHRGAA | |
| SCHEMBL9699641 | 0.73 | HPGD (0.51) | HPGDMAPTPOLBTSHRHSD17B10 | |
| SCHEMBL4908615 | 0.72 | HPGD (0.47) | HPGDMAPTPOLBTSHRNPC1 | |
| SCHEMBL7311809 | 0.72 | HPGD (0.56) | HPGDMAPTPOLBTSHRHSD17B10 | |
| SCHEMBL12680066 | 0.72 | HPGD (0.52) | HPGDMAPTTSHRHSD17B10LMNA | |
| SCHEMBL85896 | 0.72 | HPGD (0.52) | HPGDMAPTPOLBTSHRHSD17B10 | |
| SCHEMBL18157337 | 0.71 | LMNA (0.52) | HPGDMAPTPOLBTSHRGAA | |
| SCHEMBL12362338 | 0.71 | HPGD (0.51) | HPGDMAPTPOLBTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4783467-A | Tetrahydroimidazoquinazolinone inotropic agents | PFIZER INC. (US) | 1988-11-08 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0205280-A2 | Tetrahydroimidazoquinazolinone cardiac stimulants | Pfizer Limited (GB) | 1986-12-17 | — | — | EP | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |