Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7324012 | 0.93 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| Fumaric Acid SCHEMBL7330519 | 0.88 | SMN1; SMN2 (0.49) | KDM4EALDH1A1HPGDSMN1; SMN2TSHR | |
| Fumaric Acid SCHEMBL7332340 | 0.85 | LMNA (0.42) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| Fumaric Acid SCHEMBL7334775 | 0.84 | POLB (0.38) | ALDH1A1HPGDPOLBTDP1MAPT | |
| Fumaric Acid SCHEMBL7331885 | 0.84 | SMN1; SMN2 (0.48) | ALDH1A1HPGDSMN1; SMN2TSHRPOLB | |
| SCHEMBL7324842 | 0.84 | KDM4E (0.43) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| Fumaric Acid SCHEMBL7325579 | 0.83 | GAA (0.55) | KDM4EALDH1A1HPGDSMN1; SMN2TSHR | |
| Fumaric Acid SCHEMBL7334141 | 0.83 | HPGD (0.43) | KDM4EHSD17B10HPGDSMN1; SMN2MAPT | |
| Fumaric Acid SCHEMBL7324504 | 0.83 | HTR3A (0.46) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| Fumaric Acid SCHEMBL7335420 | 0.82 | KMT2A (0.43) | KDM4EALDH1A1SMN1; SMN2HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |