Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70645 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HSD17B10HPGDSMN1; SMN2RAB9A | |
| SCHEMBL5540279 | 0.80 | RAB9A (0.47) | ALDH1A2ALDH1A3ALDH1A1HSD17B10CYP2A6 | |
| SCHEMBL17626029 | 0.77 | MPL (0.49) | ALDH1A1SMN1; SMN2RAB9ACASP3SENP8 | |
| SCHEMBL2201317 | 0.77 | IDO1 (0.43) | ALDH1A1HSD17B10CYP2A6HPGDSMN1; SMN2 | |
| SCHEMBL7227702 | 0.77 | IDO1 (0.42) | ALDH1A1HSD17B10HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL27752088 | 0.75 | RAB9A (0.51) | ALDH1A1HPGDSMN1; SMN2RAB9AMAPT | |
| SCHEMBL3858714 | 0.74 | HTR2C (0.40) | ALDH1A1HSD17B10HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL17625965 | 0.74 | LMNA (0.43) | ALDH1A1MAPK1SMN1; SMN2RAB9AHTT | |
| SCHEMBL5660459 | 0.73 | VCP (0.42) | ALDH1A1HPGD | |
| SCHEMBL1435851 | 0.73 | CYP19A1 (0.47) | ALDH1A1HSD17B10HPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343894-B1 | BENZAMIDE PROTEASE INHIBITORS | PFIZER INC. (US) | 1992-06-10 | — | — | EP | claimed |
| US-4948891-A | ANTI-PLASMIN AND ANTI-THROMBIN AGENTS | PFIZER INC. (US) | 1990-08-14 | — | — | US | claimed |
| EP-0343894-A1 | Benzamide protease inhibitors | PFIZER INC. (US) | 1989-11-29 | — | — | EP | claimed |
| EP-0343894-B1 | BENZAMIDE PROTEASE INHIBITORS | PFIZER INC. (US) | 1992-06-10 | — | — | EP | disclosed |
| US-4948901-A | ANTI-PLASMIN AND ANTI-THROMBIN AGENTS | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4948891-A | ANTI-PLASMIN AND ANTI-THROMBIN AGENTS | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| EP-0343894-A1 | Benzamide protease inhibitors | PFIZER INC. (US) | 1989-11-29 | — | — | EP | disclosed |
| US-4874864-A | ANTIPLASMIN, ANTITHROMBIN AGENTS | PFIZER INC. (US) | 1989-10-17 | — | — | US | disclosed |