Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.56 |
| ▸ | MMP9 | P14780 | 9/20 | 0.56 |
| ▸ | MMP1 | P03956 | 8/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.56 |
| ▸ | MMP3 | P08254 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BMP1 | P13497 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | MMP16 | P51512 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315622 | 0.93 | MMP13 (0.46) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7313302 | 0.80 | MMP9 (0.53) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7321295 | 0.76 | MMP9 (0.49) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7317768 | 0.75 | MMP9 (0.45) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7316642 | 0.75 | MMP9 (0.48) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7315190 | 0.75 | MMP9 (0.46) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7324044 | 0.72 | MMP13 (0.48) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7316400 | 0.72 | MMP9 (0.54) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7315318 | 0.71 | MMP13 (0.52) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7312681 | 0.71 | KDM4E (0.44) | MMP13MMP9MMP1ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |