Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 7/20 | 0.39 |
| ▸ | MMP9 | P14780 | 7/20 | 0.39 |
| ▸ | MMP13 | P45452 | 7/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314106 | 0.83 | LMNA (0.43) | KDM4EMMP1MMP9MMP13MEN1 | |
| SCHEMBL7315622 | 0.77 | MMP13 (0.46) | MMP1MMP9MMP13ADAM17ALDH1A1 | |
| SCHEMBL7313738 | 0.77 | NAMPT (0.43) | KDM4EMMP1MMP9MMP13ADAM17 | |
| SCHEMBL7351590 | 0.75 | MMP9 (0.41) | KDM4EMMP1MMP9MMP13ADAM17 | |
| SCHEMBL7324193 | 0.75 | RAPGEF4 (0.48) | MMP1MMP9MMP13MEN1KMT2A | |
| SCHEMBL7325394 | 0.71 | MMP13 (0.56) | KDM4EMMP1MMP9MMP13ADAM17 | |
| SCHEMBL7323234 | 0.70 | MMP1 (0.44) | KDM4EMMP1MMP9MMP13ADAM17 | |
| SCHEMBL7318168 | 0.70 | MMP1 (0.42) | KDM4EMMP1MMP9MMP13ADAM17 | |
| SCHEMBL7317121 | 0.69 | LMNA (0.42) | MMP1MMP9MMP13ADAM17MEN1 | |
| SCHEMBL7315190 | 0.69 | MMP9 (0.46) | MMP1MMP9MMP13ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |