Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 12/20 | 0.53 |
| ▸ | HCN1 | O60741 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | HCN3 | Q9P1Z3 | 1/20 | 0.46 |
| ▸ | HCN2 | Q9UL51 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705312 | 0.71 | FNTA (0.55) | MEN1KMT2AGAATP53KDM4E | |
| SCHEMBL7325697 | 0.69 | TP53 (0.41) | GAATP53KDM4EMAPTTHRB | |
| SCHEMBL7398258 | 0.68 | KMT2A (0.54) | HCN4HCN1MEN1KMT2AGAA | |
| SCHEMBL7402458 | 0.68 | KDM4E (0.54) | HCN4HCN1MEN1KMT2AGAA | |
| SCHEMBL9531570 | 0.68 | CHRNA7 (0.52) | CHRNA7 | |
| SCHEMBL9533778 | 0.67 | HTR3A (0.57) | — | |
| SCHEMBL7335797 | 0.66 | MAPT (0.56) | HCN4HCN1MEN1KMT2AGAA | |
| SCHEMBL1761845 | 0.65 | ADRA2A (0.45) | TP53 | |
| Hydrochloric Acid SCHEMBL9684524 | 0.65 | ADRA2A (0.44) | TP53 | |
| Hydrochloric Acid SCHEMBL9684279 | 0.65 | ADRA2A (0.44) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627190-A | TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION, ORGASTROINTESTINAL DISORDERS, 5-HYDROXYTRYPTAMINE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1997-05-06 | — | — | US | disclosed |
| US-5430040-A | Anxiolytic agents, antidepressants, antiserotonine agents; treatment of psychosis, gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5280029-A | Containing imidazolo(1,5-a)pyridine | G. D. SEARLE & CO. (US) | 1994-01-18 | — | — | US | disclosed |
| US-5234921-A | Antagonists of the serotonin 5-HT3 receptor; gastrointestinal disorders; antidepressants; drug abuse | G. D. SEARLE & CO. (US) | 1993-08-10 | — | — | US | disclosed |
| US-5227377-A | Serotonin 5-HT3 receptor antagonists | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5219850-A | Anyiolytic agents, gastrointestinal disorders, antiserotonin agents | G. D. SEARLE & CO. (US) | 1993-06-15 | — | — | US | disclosed |
| US-5196547-A | Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof | G. D. SEARLE & CO. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5137893-A | Anxilytic agents; antidepressants; antiemetics | G. D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |